Welcome to the Kim Lab!

We study malaria, a mosquito-borne disease caused by sporozoan parasites of the genus Plasmodium. We use established mouse models of malaria infection to dissect the components of the host immune response that are important for control of this disease. We're particularly interested in the very early steps of the immune response to malaria, which are mediated by the innate immune system - the body's first line of defense against pathogenic attack. We use a variety of tools to study innate immune responses to malaria, but we're particularly interested in systems biological approaches - for example, analyzing global transcriptional responses to identify interesting patterns of gene expression. We are situated in the Division of Experimental Medicine at UCSF, where we have the opportunity to share data and ideas with investigators of human malaria. Read on to learn more!



Why are we studying malaria?

Malaria is one of the most serious infectious diseases worldwide, causing some 300 million cases of illness and up to 2 million deaths annually. Today, over a century after the Plasmodium parasite was first discovered, we still have only a limited understanding of what constitutes an effective immune response against this pathogen. This gap in our knowledge has hampered efforts to develop an effective vaccine. By working out the immune requirements for control of malaria infection in mice, we hope to provide a clearer picture of what a vaccine needs to do in order to stimulate a protective response in humans.





Latest News

New paper published in Nature Immunology!

We are looking for a technician. Look for our posting on the UCSF Careers website.